Tylosin is a coccidiostatic food
additive used in veterinary medicine. It has a broad spectrum of activity
against gram positives and a limited range of gram negatives but has been shown
to be active against Campylobacter, E. coli, and spirochaetes. It is
extremely active against Mycoplasma species isolated from both mammalian and
avian hosts [. It is found naturally as a fermentation product of
Like other macrolides, tylosin has a bacteriostatic effect on susceptible organisms, caused by inhibition of protein synthesis through binding to the 50S subunit of the bacterial ribosome.
Tylosin has been used to treat a variety of different diseases. In general, tylosin is licensed for the treatment of infections caused by organisms susceptible to the drug, but it has also been used as a treatment of colitis in small animals, as a growth promotant in food producing animals. Examples of bacterial infections that could potentially be treated with tylosin include respiratory infections, metritis, and acute mastitis in cattle; mastitis in sheep and goats; enteritis, pneumonia, erysipelas, and infectious arthritis in swine; and soft tissue infections in small animals. While tylosin may be one appropriate therapeutic choice in theory for the conditions listed above.
Oral administration can result in
diarrhoea and gastrointestinal disturbance. This is particularly true of horses,
such that it can be fatal. Tylosin also has a foul taste that is difficult to
disguise. The injectable formulations of tylosin can cause pain, inflammation,
and itchiness around the injection site.
CAS number: 1401-69-0 EINECS:
Molecular Formula: C46H77NO17
1. Antimicrobial Therapy in Veterinary Medicine, by Steeve Giguere, P. M. Dowling, ISBN 978-0-8138-0656-3
Send mail to
questions or comments about this web site.