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Cefcapene
Cefdaloxime
Cefdinir
Cefditoren
Cefetamet
Cefixime
Cefmenoxime
Cefodizime
Cefoperazone
Cefotaxime
Cefpimizole
Cefpiramide
Cefpodoxime
Cefsulodin
Ceftazidime
Cefteram
Ceftibuten
Ceftiolene
Ceftizoxime
Ceftriaxone

Third generation cephalosporins

The third generation cephalosporins include: Cefixime, Ceftriaxone, Ceftazidime, Cefoperazone, Cefcapene, Cefdaloxime, Cefdinir, Cefditoren, Cefetamet, Cefmenoxime, Cefodizime, Cefotaxime, Cefpimizole, Cefpiramide, Cefpodoxime, Cefsulodin, Cefteram, Ceftibuten, Ceftiolene, Ceftizoxime.

Third generation combine almost complete stability to most b-lactamases with much improved intrinsic activity. Cefotaxime was the first of this group of compounds, but several others are available: ceftizoxime and cefmenoxime are similar to cefotaxime; ceftriaxone displays a sufficiently long plasma half-life to warrant once-daily administration; cefodizime is said to possess immunomodulating properties.

Ceftazidime, cefpirome, and cefepime add activity against P. aeruginosa to broad-spectrum activity comparable with that of cefotaxime and its congeners. These compounds have established a useful role in the management of P. aeruginosa infections in seriously ill patients. However, the antistaphylococcal activity is weak and cefpirome may have some advantage in this respect. Cefepime retains activity against some opportunist Gram-negative bacilli that develop resistance to cefotaxime and its relatives. Among other antipseudomonal cephalosporins, cefoperazone, cefpimizole, and cefpiramide have similar spectrum and cefsulodin is extraordinary in being virtually inactive against bacteria other than P. aeruginosa.

 

 

 

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