Thiamphenicol is the methyl-sulfonyl analogue of chloramphenicol and has a similar spectrum of activity, but is 2.5 to 5 times more potent. It is insoluble in water, but highly soluble in lipids. Thiamphenicol is used in many countries as a veterinary antibiotic, but is available in China and Italy for use in humans. Its main advantage over chloramphenicol is that it has never been associated with aplastic anaemia.
Unlike chloramphenicol, thiamphenicol is is not readily metabolized in cattle, poultry, sheep, or humans, but is predominantly excreted unchanged.
CAS number: 15318-45-3 EINECS:
Molecular Formula: C12H15Cl2NO5S
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