Second generation cephalosporins
The second generation cephalosporins include: Cefaclor, Cefamandole, Cefminox, Cefonicid, Ceforanide, Cefotiam, Cefprozil, Cefbuperazone, Cefuroxime, Cefuzonam, Cephamycin, Cefoxitin, Cefotetan, Cefmetazole.
An important advance was achieved with
the development of cephalosporins that show good stability to the common
b-lactamases of enterobacteria such as E. coli
and Klebsiella aerogenes. Among them cefuroxime and cefoxitin, the latter
being one of a group of cephalosporins, collectively called cephamycins, which
have a b-lactam ring modified by the addition of a
stabilizing methoxy substituent. Other cephamycins available in some countries
include cefotetan, cefmetazole, and cefminox. The cephamycins show a particular
useful activity against anaerobes of the Bacteroides fragilis group.
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