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Cefaclor
Cefamandole
Cefbuperazone
Cefminox
Cefmetazole
Cefonicid
Ceforanide
Cefotetan
Cefotiam
Cefoxitin
Cefprozil
Cefuroxime
Cefuzonam
Cephamycin

Second generation cephalosporins

The second generation cephalosporins include: Cefaclor, Cefamandole, Cefminox, Cefonicid, Ceforanide, Cefotiam, Cefprozil, Cefbuperazone, Cefuroxime, Cefuzonam, Cephamycin, Cefoxitin, Cefotetan, Cefmetazole.

An important advance was achieved with the development of cephalosporins that show good stability to the common b-lactamases of enterobacteria such as E. coli and Klebsiella aerogenes. Among them cefuroxime and cefoxitin, the latter being one of a group of cephalosporins, collectively called cephamycins, which have a b-lactam ring modified by the addition of a stabilizing methoxy substituent. Other cephamycins available in some countries include cefotetan, cefmetazole, and cefminox. The cephamycins show a particular useful activity against anaerobes of the Bacteroides fragilis group.
 

 

 

 

 

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