Phosphomycin synthesis and antibacterial activity


Mechanism of Action

Phosphomycin inhibits the pyruvyl transferase enzyme that brings about the condensation of phosphoenolpyruvate and N-acetylglucosamine in the formation of N-acetylmuramic acid. Gram-positive cocci are less susceptible than Gram-negative rods. The precise level of activity is not clearly understood, since the in-vitro activity can be manipulated by altering the test medium. Glucose-6-phosphate potentiates the activity against many Gram-negative bacilli by inducing the active transport of phosphomycin into the bacterial cell.


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