Phosphomycin is a naturally occurring antibiotic originally obtained from a species of Streptomyces isolated in Spain. It is formulated as the sodium salt for parenteral use, but this is unsuitable for oral administration. It is well tolerated, and the ready emergence of bacterial resistance that is observed in vitro does not appear to have been a major problem in treatment. The trometamol (tromethamine) salt, which is highly soluble, well absorbed, and excreted in high concentration in urine, is suitable for oral therapy of uncomplicated cystitis.


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