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Oxazolidinones

Oxazolidinones have attracted attention owing to their activity against Gram-positive organisms, including staphylococci, pneumococci, and enterococci. They are well absorbed by the oral route and exhibit bacteriostatic activity. They act at an early stage in protein synthesis by blocking the formation of the 70 S initiation complex. An important feature of these compounds is that they do not show cross-resistance to other classes of antibiotics.

The most widely investigated member of the family, linezolid, has been in use for the treatment of MRSA infection  and has gained a significant market reaching blockbuster status. The drug is active against M. tuberculosis and there is some evidence that it might be useful in infections with drug-resistant strains. The main limitation of linezolid is an effect on bone marrow cells that largely limits the length of treatment to 2 weeks.

Oxazolidinones are protein synthesis inhibitors and include: Linezolid, Torezolid, Eperezolid, Posizolid, Radezolid.

 


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