Glycylcyclines are a new class of antibiotics derived from tetracycline [1-2]. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance, namely resistance mediated by acquired efflux pumps and/or ribosomal protection. Glycylcycline antibiotics have a similar mechanism of action as tetracycline antibiotics. Both classes of antibiotics bind to the 30S ribosomal subunit to prevent the amino-acyl tRNA from binding to the A site of the ribosome. However, the glycylcyclines appear to bind more effectively than the tetracyclines.

1. Rose W, Rybak M. "Tigecycline: first of a new class of antimicrobial agents". Pharmacotherapy 2006, 26 (8): 1099110.

2. Kasbekar N. "Tigecycline: a new glycylcycline antimicrobial agent.". Am. J. Health Syst. Pharm. 2006, 63 (13): 123543.


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