Daptomycin is a semi-synthetic lipopeptide antibiotic with a structure similar to polymyxins, that has various effects on bacteria, whose  primary mode of action is thought to lie in disruption of the cell membrane. Development of the compound in the 1980s was stopped because of potential toxicity, but the rise of multiresistant Gram-positives revived interest and it is now marketed for serious infections of the skin and soft tissues that are unresponsive to other agents, especially those caused by multiresistant staphylococci. Activity is restricted to Gram-positive cocci and is greatly enhanced in vitro by the presence of magnesium ions.


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