b-lactamases are responsible for the resistance of many bacteria to b-lactam antibiotics. Many b-lactamase inhibitors have been investigated, and the three which are most suitable for clinical use are clavulanic acid, sulbactam, and tazobactam.
Clavulanic acid is a naturally occurring b-lactamase inhibitor which was isolated from Streptomyces clavuligerus . It contains a b-lactam ring but, unlike the penicillins and cephalosporins, it shows only a low level of antibacterial activity.
Dosage and Administration
The drug is not orally available.
Mechanism of Action
Other pharmacological effects
1. Reading C., Cole M. "Clavulanic acid: a beta-lactamase-inhibiting betalactam from Streptomyces clavuligerus". Antimicrob. Agents Chemother. 11: 852, (1977).
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