Clometocillin, whose tradename is Rixapen  is
an anti Gram positive penicillin  indicated for the treatment of
respiratory system and skin with streptococci, in dental abscess and in
preventing the reappearance of acute articular rheumatism.
Dosage and Administration
Mechanism of Action
In a study with 21 antibiotics, clometocillin was the
most active penicillin against pen-I or pen-R pneumococci 
(see table 1).
Table 1. Susceptibility of pneumococci to
Optical rotation: [a]D
+210-220°. The free acid yields two diastereoisomers: [a]D
+177° and [a]D +257°.
1. Vanderhaeghe et al., "Semi-synthetic
antibiotic related to penicillin". Antimicrob. Agents Chemother. 581,
2. van Dijck et al., Antibiot. Chemother. 12,
3. Verhaegen J., Verbist L. "In-vitro
activity of 21 b-lactam antibiotics against
penicillin-susceptible and penicillin-resistant Streptococcus pneumoniae".
J. Antimicrob. Chemother. 41, 381–385, (1998).