It is never too early to identify a chemical synthesis
suitable for development. Usually the chemical synthesis used in
medicinal chemistry during lead optimisation is designed to synthetise
several analogs and is not optimised to maximise yields. Priority is
given to the rapidity with which compounds are produced and tested.
the contrary, when a molecule approaches chemical development,
reproducibility, robustness, cost, number of steps, impurity profile are
some of the elements that have to be taken into consideration.
Chemical route design is an essential step in approaching GMP
manufacturing. The robustness of the process and the cost of goods are
strongly influenced by this activity. If properly performed allows to
have a smooth drug development avoiding unnecessary, costly and time consuming
- Reduced cost of development
- Robust manufacturing process