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Chemical route design and process optimisation

It is never too early to identify a chemical synthesis suitable for development. Usually the chemical synthesis used in medicinal chemistry during lead optimisation is designed to synthetise several analogs and is not optimised to maximise yields. Priority is given to the rapidity with which compounds are produced and tested.

On the contrary, when a molecule approaches chemical development, reproducibility, robustness, cost, number of steps, impurity profile are some of the elements that have to be taken into consideration.

Chemical route design is an essential step in approaching GMP manufacturing. The robustness of the process and the cost of goods are strongly influenced by this activity. If properly performed allows to have a smooth drug development avoiding unnecessary, costly and time consuming activities.

Key Benefits

  • Reduced cost of development
  • Robust manufacturing process

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For More Information Contact:

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via Copernico 22, 20016 Pero (MI), Italy
Tel: +39 02 36593963
FAX: +39 02 36593963
Internet: stefano.biondi@innovativesolution.it 

 

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