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Clarithromycin
Dirithromycin
Erythromycin
Flurithromycin
Oleandomycin
Rokitamycin
Roxithromycin
Troleandomycin

14 membered ring

 14 membered macrolides constitute a class of antibiotics that have first been isolated from natural sources and has been subject of intensive studies to obtain a number of derivatives that have clinical use. Efforts to modify the properties of erythromycin have been more successful in generating compounds with improved pharmacological features rather than enhanced antibacterial activity. Much interest has centred on altering the molecule in such a way that the reactive groups responsible for the acid lability are modified. Such changes increase the bioavailability and often extend the plasma half-life. Any improvement in antibacterial activity is generally modest, but enhanced tissue penetration may render these compounds more effective. Acid-stable derivatives of erythromycin also appear to be less prone to cause gastrointestinal upset.

This class of antibiotics contain both natural and synthetic compounds and include: Clarithromycin, Dirithromycin, Erythromycin, Flurithromycin, Oleandomycin, Rokitamycin, Roxithromycin, Troleandomycin.

 

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